- Brain fog is a very weird phenomenon that doesn't even actually have a term in medicine, we refer to that as cognitive fatigue or mental fatigue, where you feel like your brain just won't turn on that everything takes a huge effort and you're having trouble accessing information.

Words won't come to mind, really.

What is really concerning I think, is that these changes can be so severe to prompt fears of either going crazy or being developing dementia.

The purpose of the clinical trial is to test the efficacy of a selective estrogen receptor modulator for hot flashes, but also for support of cognitive function and potentially for prevention of Alzheimer's disease.

And the way that we test this is by working with women who are going through menopause.

Menopause has been historically pigeonholed as an issue with the ovaries, which means that you go to your OB-GYN and OB-GYNs don't do brains, right?

It's not their fault, they're just not trained.

Those are neurologists, psychiatrists, neuroendocrinologist, neuropsychologists, anything with the neuro in there.

We do brains.

Obviously we need to change the framework around menopause where it's understood that there's an ovarian component and the brain component.

From a basic science perspective, there is a lot of evidence that supplementing hormones that ovaries no longer make with hormones that come from the outside has potential to support brain health and even possibly lower the risk of some neurological or psychiatric concerns like depression, anxiety, Parkinson's disease, Alzheimer's disease.